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Exercise counseling and reduced calorie diet 68 weeks

Those excluding medications for weight loss may be doing so due to budget constraints

GIP (Glucose-dependent Insulinotropic Polypeptide): The addition of GIP agonism provides synergistic effects

BMI 27 with weight-related conditions, such as: Type 2 diabetes or prediabetes Hypertension High cholesterol Sleep apnea Fatty liver disease (NAFLD) PCOS Insulin resistance Patients in this range may be candidates because GLP-1 medications act on pathways related to blood sugar, appetite, and metabolic regulation

Shearer J, Shah S, MacInnis MJ, Shen-Tu G, Mu C

There was no loss to followup, and none emigrated during followup