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Il peptide influenza anche l'espressione dei geni coinvolti nella produzione di collagene di tipo I e III

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When hepatocytes encounter excess copper, endolysosomal vesicles containing ATP7B transport it to the bile ducts, excreting the surplus copper ions into the bile [10]

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This profile not only involves high levels of PAI-1 and STAT3 as previously described, but also includes low levels of glutamine and NAD + , coupled with overproduction of hyaluronan (HA)

174 In conclusion, NDCDS in response to ROS can be designed based on the high ROS level in the tumor microenvironment to achieve drug release within the tumor, thereby playing the role of targeting tumors