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Therefore, the inability to maintain NRF2 protein expression is directly associated with poor prognosis in clinical patients diagnosed with lung cancer.16,19,20 The Cancer Genome Atlas (TCGA) data showed that approximately 30% of human lung cancers harbor mutations in KEAP1 or NFE2L2 genes that ultimately lead to NRF2 stabilization and upregulation of its downstream genes.21,22 NRF2 signaling pathway in oncogenesis Loss of KEAP1 function leads to defective activation of the NRF2 signaling pathway in NSCLC cells, resulting in resistance to chemotherapeutic agents.13 The inability of KEAP1 to bind NRF2 due to both mutations results in increased NRF2 accumulation and downstream gene transcription
10.1167/iovs.63.4.27 [DOI] [PMC free article] [PubMed] [Google Scholar] Wang L., Zhang L., Niu Y., Sitia R., Wang C
A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility
Los estudios han demostrado que este pptido puede promover la secrecin de factores reguladores inmunitarios, como la timosina y la timosina humana, y mejorar la funcin inmunitaria
This is why there has been a rise in the usage of medicinal plants because of their superior health philosophy and lack of adverse drug reactions
2023 Jan 1;78(1):75-89
