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This once-daily shift increases compliance, reduces side effects (due to dissipation of peak adverse effects during sleep), and is, importantly, renal sparing.[33] Sustained release (SR) preparations of lithium may be preferred over the IR preparation in case of upper gastrointestinal side effects (e.g., nausea, which is lower with the SR preparation)

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According to the hypothesis proposed by Fabian-Fine et al

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Beyond Medication: Lifestyle as the Cornerstone Even with highly effective medications like semaglutide or tirzepatide, lifestyle interventions remain the bedrock of sustainable weight loss and overall health