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Lancet Diabetes Endocrinol 12(3): 184-195
Beloranib Beloranib inhibits methionine aminopeptidase 2 (MetAP2), leading to hormonal changes that decrease fat biosynthesis, enhance fat oxidation, and increase lipolysis
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Trends Endocrinol Metab (2015) 26(4):193200

However, sustained HIF-1 activation in the context of neurodegeneration may exacerbate inflammation and promote A production, thereby worsening synaptic dysfunction and neuronal damage (Zhang et al., 2007)

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