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Step 2: Water is added across the double bond to give an alcohol at the beta carbon (Figure 20.8) Next, the alkene is hydrated, i.e ., the elements of water are added across the double bond, to give an alcohol at the beta carbon

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received lecture and/or consultancy fees from AstraZeneca, Boehringer-Ingelheim, Lilly, Novo Nordisk, Novartis, and Sanofi

When undergoing ketogenic diets, starvation, or ketoacidosis, the blood concentration of -HB increases, which activates GPR190A to reduce lipolysis in adipose tissue, thereby decreasing the entry of nonesterified fatty acids into the liver for ketone synthesis and forming a negative feedback mechanism (Kimura et al., 2011)

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