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Key variants in GLP1R, GIPR, FTO, and MC4R genes can affect appetite signaling, energy metabolism, and gastrointestinal sensitivity, potentially shaping which GLP-1 formulation works best

It is possible that participants in the group with neither weight loss nor glucose reduction discontinued or only sporadically used the drug, so we focused on those who achieved a reduction in either outcome, as it is more likely that these individuals used the drug as prescribed

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