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This effect is thought to be mediated by increasing natriuresis (35) and vasorelaxation in the renal vasculature (36)

Sometimes, switching from one GLP-1 to another becomes necessary, and its not always as simple as swapping injection pens

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Exendin-4 was ultimately synthesized to Exenatide, a GLP-1RA with a half-life sufficient to permit clinical use in treating type 2 diabetes, the first in a new generation of drugs that followed

doi: 10.1002/cne.24905, 55 GrahamD

Combinations of GLP-1 with other entero-pancreatic hormones with complementary actions and/or synergistic potential (such as glucose-dependent insulinotropic polypeptide (GIP), glucagon, and amylin) are under investigation to enhance the weight loss and cardiometabolic benefits of GLP-1 RA [21]