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Description
Excessive accumulation of indoxyl sulfate causes cardiomyocyte damage and increases thrombus formation [172]

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Nuclear SIRT1, SIRT6, and SIRT7 are key regulators of DNA repair and genome stability

Int J Physiol Pathophysiol Pharmacol 11:4563 Rabbani N, Xue M, Thornalley PJ (2022) Hexokinase-2-linked glycolytic overload and unscheduled glycolysis-driver of insulin resistance and development of vascular complications of diabetes

Therefore, rectifying the M1/M2 imbalance has emerged as a promising therapeutic strategy for OA management, aimed at restoring synovial homeostasis and mitigating joint destruction

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