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Healthcare System Impact The substantial 2025 sales figures highlight the financial pressure that semaglutide medications have placed on both private insurance plans and individual patients paying out-of-pocket

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This dysfunction is linked to enhanced activation of key signaling pathways and molecules, including Rho-associated kinase 2 (ROCK2), p38 mitogen-activated protein kinase (p38 MAPK), and arginase II [35]

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