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Ozempic and Wegovy (and Rybelsus, which is oral semaglutide) are GLP-1 receptor agonists (glucagon-like peptide-1 receptor agonists, commonly referred to as GLP-1s) and are the only FDA-approved drugs that contain the active ingredient semaglutide

Work from the group of Renate Schreiber and Rudy Zechner demonstrated that PNPLA2 in BAT is not required for cold-induced thermogenesis, suggesting that other BAT lipases such as HSL or Carboxylesterase 3 (Ces3) (101) may suffice

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