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Tachyphylaxis Rapid Exhaustion of the Readily Releasable Pool : The primary neurobiological mechanism driving acute stimulant tolerance is the rapid exhaustion of the readily releasable pool (RRP) of synaptic vesicles (Kaeser and Regehr, 2017

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On the other hand, when only NAD+ is supported: Cells may produce energy more efficiently, but oxidative stress may still place a burden on them

doi:10.1016/j.bbadis.2011.10.

Glutaminedependent changes in gene expression and protein activity