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Current approved indications are limited to type 2 diabetes mellitus and chronic weight management (for specific agents at designated doses)

Korownyk C Lifestyle interventions for patients with and at risk for type 2 diabetes: A systematic review and meta-analysis

[PharmNews=Eung-Min Kim] As obesity has emerged as a major global public health issue, glucagon-like peptide-1 (GLP-1) receptor agonists have drawn attention as an effective treatment option for weight loss and glycemic control

Endocrinology 156: 255267, 2015

Aetna's clinical policy bulletin (CPB 0784) now expects documented weight management attempts of at least 6 months before approving GLP-1 coverage on most plans (up from 3 months on some 2025 plans)