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Hughes traces the transformations of tobacco and its use over time, from its role as a hallucinogen in Native American shamanistic ritual to its use as a prophylactic against the plague and a cure for cancer by early Europeans, and finally to the current view of smoking as a global pandemic

export value in 2025: $900M Top exports: Leaf tobacco (Burley, Virginia) Top destinations: China, the EU, and Turkey 2

Smoke: a global history of smoking

The Health Consequences of Smoking - 50 Years of Progress: A Report of the Surgeon General

Conclusion The cotinine test does not determine smoker status

In fact, the FDA has not authorized any electronic nicotine replacement system (ENDS) as a tool to help people quit smoking