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Moreover, another limitation of many studies was the lack of adjustment within the analytic model for the degree of HbA 1c reduction while on the drug, because this is the leading hypothesis of the mechanism of this relationship

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Your prescriber submits documentation showing medical necessity: BMI 30+, or BMI 27+ with a comorbidity, and often proof that diet and exercise alone were insufficient

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But many questions remain including its long-term safety profile, effect on lean body mass and bone mineral density, real-world tolerability, and ultimate UK pricing once and if MHRA approval is granted