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After appearances in film and on television, Ryder continued her acting career with the cult film Heathers (1988), a controversial satire of teenage suicide and high school life that has since become a landmark teen film

To elucidate these pathophysiological processes, we examined the in vitro and in vivo effects of CS extract (CSE) and CS on the transcription factor, hypoxia-inducible factor 1 (HIF-1)