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US Department of Health and Human Services, National Institutes of Health, Office of Dietary Supplements

Copper accumulation also becomes a theoretical concern at extreme doses, though practical protocols stay well below problematic thresholds

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10.1152/ajpgi.00547.2011 150 ZhengJ.BabygirijaR.BulbulM.CerjakD.LudwigK.TakahashiT

Ghrelin acts after being acylated by ghrelin O-acyl-transferase (GOAT), which binds a fatty acid side chain (C8) to serine 3 of ghrelin, forming acyl ghrelin, the active form, which acts on its receptor, a G-protein-coupled receptor (GHSR-1a)

It is advisable to consult a specialist before starting a new treatment or supplement regimen