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Berberine is generally safe but may cause mild side effects, especially at higher doses:[4] Digestive issues : Nausea, diarrhea, constipation, or bloating (start with 300 mg daily to minimize)

Sulfur burps and other GI side effects can make eating sufficient protein difficult, accelerating lean mass loss

As a GIP receptor agonist, tirzepatide enhances insulin secretion in a glucose-dependent manner, reduces glucagon secretion, and may improve insulin sensitivity

Tau and -synuclein in susceptibility to, and dementia in, Parkinsons disease

Its also best to budget for the drug, which requires a prescription, if it isnt covered by an insurance provider, as the pills can cost close to $1,000

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