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Chronic overeating, insulin resistance, sleep deprivation, and stress can all disrupt these signals, resulting in persistent weight gain or difficulty losing weight despite lifestyle changes

J., Vlund, A

Thanks again for listening

High Blood Press Cardiovasc Prev 24:107114 Tanaka A, Shimabukuro M, Okada Y, Sugimoto K, Kurozumi A, Torimoto K, Hirai H, Node K (2020) PROCEED trial investigators

This points to a possible efficacy advantage compared to Rezdiffra

Jastreboff, et al., 'Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA', Lancet , vol