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A structured search strategy was used to identify in vitro, animal, and human studies that assessed vitamin B-12 status, dietary intake, or supplementation, and the gut microbiome using culture-independent techniques

In particular, CD38 may have a role not only in the regulation of intracellular but also extracellular NAD, and may modulate the availability on extracellular applied NAD in some cellular systems

The first method used a Basic Local Alignment Search Tool Nucleotide (BLASTn

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