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The relative expression of each target gene was normalized to that of -actin

Results in WT INS-1 832/3 cells (expressing endogenous levels of GLP-1R) show VAPB-localised cAMP responses with both agonists, which are less pronounced for the slow internalising exendin-F1 compared to exendin-4, demonstrating that GLP-1R actively signals at VAPB loci

Gao L, Huang H, Zhang L, et al

doi: 10.2337/dc17-2285

In summary, GLP-1RA could reduce the proliferation of effector T cells, promote the generation of Treg cells, and enhance the immunosuppressive function of Treg cells ( Figure 3 ) (91)