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Primer pairs were designed using NCBI PrimerBlast (Table S3)

Biochemical and Biophysical Research Communications, 447(4), 707714

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The genetic test does not predict which peptide will work best or guarantee response, but variants in GH pathway genes may support a more nuanced conversation between patient and provider about individual metabolic potential and baseline risk factors for peptide-related side effects

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Under hyperglycemic conditions, dysfunction of the mitochondrial electron transport chain (ETC.) leads to excessive ROS production, subsequently inducing oxidative damage, mitochondrial DNA (mtDNA) mutations/leakage, and activation of inflammatory pathways such as the NLR family pyrin domain containing 3 (NLRP3) inflammasome and the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING), thereby exacerbating local and systemic inflammation and hindering wound healing (Wang et al., 2025a