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A negative correlation between TT genotype and CRC was observed in ethnics of Asians (OR=0.83, 95% CI: 0.76, 0.91), Caucasians (OR=0.93, 95% CI: 0.88, 0.99) and the region of USA (OR=0.77, 95% CI: 0.71, 0.85), Asia (OR=0.93, 95% CI: 0.86, 1.00) and Europe (OR=0.93, 95% CI:0.87, 1.00),but not in Indian (TT: OR=1.67, 95% CI: 1.06, 2.63

Collectively, our findings reveal that KRT14 contributes to chemoresistance in BLCA not only via its structural roles but also by directly regulating translational machinery through eIF4H, leading to upregulation of the metabolic enzyme ACOX2