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It is important to know that for some folks, empty stomach use can increase the likelihood of nausea or GI symptoms. Meacham says yes

Obesity and overweight, which are common in patients with DM2, are a factors that favor the development/progression of CKD through both direct and indirect effects.69 Although the precise mechanisms the association between obesity and CKD are not totally defined it has been proposed that hypertension, glomerular hyperfiltration, hyperglycemia, lipid toxicity, inflammation or the role of adipose tissue and its adipokines are involved.70 Weight reduction by bariatric surgery, pharmacological treatment or dietary measures are associated with a nephroprotective effect,7173 so that weight reduction is a fundamental objective in the nephroprotection of patients with DKD

[3] Pancreatic proglucagon gene expression is promoted upon fasting and hypoglycaemia induction and inhibited by insulin

Questions to Ask a Registered Dietician or Your Licensed Healthcare Provider Get Thin MD patients get access to a Registered Dietician

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The most common side effects are nausea, reflux, constipation, diarrhea, bloating, and fatigue