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Description
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This allows compound 2 to execute positive allosteric modulation through enhancement of both agonist binding and G protein coupling

Purpose Chronic kidney disease (CKD) is one of the most common complications of type 2 diabetes (T2D), and CKD-related disability and mortality are increasing despite the recent advances in diabetes management

- **Curb appetite:** Helping individuals feel full, potentially leading to reduced food intake

GLP-1 RAs have been used for diabetes and found to improve CV outcomes in diabetic and nondiabetic patients

We already know that GLP-1s act on the brain in various ways
