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Yes, persistent or worsening fatigue despite GLP-1 treatment warrants medical review to investigate other potential causes such as anaemia, thyroid disorders, sleep apnoea, depression, or medication side effects

This can help determine whether the medication being offered corresponds to an FDA-approved product or a compounded formulation

doi:10.1016/s0140-6736(07)60751-x

Begin with a first-line medication for alcohol use disorder and proven behavior strategies

Brain Pathol (2014) 24(3):2619

And yet an important scientific question remains unresolved: how much of these benefits are mediated by weight loss itself, and how much reflect direct cellular and tissue-specific effects of GLP-1 signaling