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There is a discrepancy between the magnitude of improvement in glycemic control and the weight loss, cardiovascular, and renal benefits obtained in large clinical trials

Once weekly subcutaneous injection

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Glucagon-like peptide-1 (GLP-1) and serotonin play critical roles in energy balance regulation

The survival benefit was more pronounced in younger people and those with cardiometabolic comorbidities, highlighting the need for a careful riskbenefit evaluation when prescribing GLP-1 RAs in high-risk individuals.