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The doctor may need to consider prior dose, side effects, current appetite, blood sugar status, constipation or nausea history, hydration, weight trajectory, lab markers, cost, access, and maintenance goals

Published June 10, 2026

N Engl J Med 375 , 311322, (2016)

This is particularly relevant for patients on semaglutide, since GI AEs, such as nausea and bloating, might be aggravated by low-grade systemic inflammation [125]
