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Remethylation requires folate and vitamin B12 (or betaine as an alternative), while transsulfuration requires pyridoxal-5-phosphate (PLP)

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Mass spectrometry analysis revealed a threefold increase in markers of neuronal membrane lipid peroxidation in Bmal1 knockout mice, reflecting heightened neuronal oxidative damage [179]

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Its anti-inflammatory effects are primarily attributed to inhibition of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), as well as attenuation of NF-B signaling

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