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Lower estrogen, reduced activity over time, and menopause-related sleep disruption often work together to drive steady weight gainabout 1.5 pounds per year on average after menopause

2023 Nov;176(11):JC129

-Patients taking Wegovy had an average weight loss of 14.9% after 68 weeks 1 -Patients who took Saxenda had between 5 and 10% weight loss compared with placebo after 56 weeks 2 Medically supervised weight management with GLP-1 prescriptions or refills available online Most GLP-1 side effects are associated with mild abdominal discomfort

22 For Constipation: Gradually increasing dietary fiber intake from sources like fruits, vegetables, whole grains, and legumes is key, but must be paired with drinking plenty of water

This spreads to other facets of peoples lives too: many patients report experiencing social situations and the world differently after losing weight

Side Effects Across Different Dosage Levels Side effects typically intensify with each dose increase, though the pattern varies significantly between individuals: Starter Doses (Wegovy 0.25-0.5mg, Zepbound 2.5-5mg) Common: Mild nausea, reduced appetite, occasional constipation Less common: Mild heartburn, slight fatigue Rare at this stage: Severe vomiting, intense gastrointestinal distress Middle Doses (Wegovy 1-1.7mg, Zepbound 7.5-10mg) Common: Moderate nausea (often worse after meals), constipation, occasional vomiting, delayed gastric emptying (feeling full longer) Less common: Headaches, fatigue, sulfur burps, acid reflux Rare but reported: Hair thinning (typically temporary), gallbladder issues Maintenance Doses (Wegovy 2.4mg, Zepbound 12.5-15mg) Common: All of the above, potentially more pronounced Additional concerns: Muscle loss if protein intake isn't adequate Long-term considerations: Nutritional deficiencies due to reduced food intake, delayed gastric emptying Tolerance Development: Does the Effect Diminish Over Time