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The article explores how medications like semaglutide and tirzepatide, originally approved for diabetes and obesity, are increasingly being prescribed off-label to address underlying metabolic issues such as insulin resistance, weight gain, and hormonal []

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However, there was progress in the UK where the government announced Scotland CardioMetabolic Impact Study (SCoMIS) , a pioneering Real-World study, which will provide Wegovy to between 3,000-5,000 people living with Obesity in Scotlands poorest areas free of charge during a three year study [11] Despite FDA phasing out enforcement discretion that allowed GLP-1 compounding during shortages - and setting May 2025 deadlines for compounding to cease - compounding has continued beyond this deadline [12]

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