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Description
This slow release is why many of these medications only need to be administered once per week

Because there are so many now
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Orforglipron (LY3502970), a novel, oral non-peptide glucagon-like peptide-1 receptor agonist: a Phase 1a, blinded, placebo-controlled, randomized, single- and multiple-ascending-dose study in healthy participants

doi: 10.1172/jci.insight.140532 110 ZhaoFZhouQCongZHangKZouXZhangCet al
A systematic review of the antidepressant effects of glucagon-like peptide 1 (GLP-1) functional agonists: further link between metabolism and psychopathology: special section on translational and neuroscience studies in affective disorders
