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Animal Data Female rats given subcutaneous doses of 0.1, 0.25 and 1.0 mg/kg/day liraglutide beginning 2 weeks before mating through gestation day 17 had estimated systemic exposures 0.8-, 3-, and 11-times the human exposure at the MRHD based on plasma AUC comparison

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In summary, as time progresses and systems improve, the number of ADE reports for semaglutide may increase, and its safety signal spectrum may continually evolve

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Phase 2a MASH data showed up to 82% liver fat reduction

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