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Brucein D, a naturally occurring quassinoid, enhances the sensitivity of pancreatic ductal adenocarcinoma (PDAC) cells to gemcitabine (GEM) by promoting the ubiquitin-proteasome-dependent degradation of NRF2 and suppression of the NRF2 signaling pathway [104]

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Each photometer unit includes an integrated detector package consisting of a photomultiplier tube, high voltage power supply, and pulse amplitude discriminator electronics

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This signal suggests influence on early pathogenic processes rather than established neurodegeneration