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Antipyretic effects are thought to be due to the central (CNS) inhibition of COX-1 and COX-2 variant enzymes

Punjani A, Rubinstein JL, Fleet DJ, Brubaker MA

The findings of this meta-analysis demonstrated that silymarin at a dose of less than 400 mg showed greater decreasing effects on AST and ALT levels compared to its high doses

Hematology (2019) 24(1):74250

Targeting the PI3K/mTOR axis, alone and in combination with autophagy blockade, for the treatment of malignant peripheral nerve sheath tumors

Cerebral Blood Flow Improvement Repairs damaged cerebral microvasculature through angiogenesis promotion, endothelial cell survival enhancement, and blood-brain barrier integrity restoration