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Moreover, strict regulatory oversight, limited peptide synthesis capacity, and dependency on specialized ingredients contribute to delays
CBO notes that some analyses of weight loss via GLP-1s found they reduced all-cause mortality in certain patients, while other methods had mixed results notably bariatric surgery, which did not clearly lower future health spending and was heavily dependent on individual adherence to post-surgery lifestyle changes

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Sandoval et al., 2008
& Paolisso, G

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