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Glutathione peroxidase enzymes may also have roles in metabolizing nitric oxide oxidation products, such as peroxynitrite, 6 in ways that prevent their depletion of tetrahydrobiopterin, a cofactor needed for preventing nitric oxide synthase uncoupling or efficient nitric oxide generation

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Therefore the ratio of GSH: GSSG is an important indicator of cellular redox status

Individual p38 MAPK isoforms often exert distinctand at times opposingbiological functions

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