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8 This process drives the contraction of the nave T cell compartment and expansion of the memory T cell pool, ultimately leading to a reduced diversity of the available T cell receptor (TCR) repertoire

FOXOs are essential regulators of osteoclast differentiation and bone resorption by decreasing the ROS ( 2 O 2 ( Figure 1 Molecular Interaction Between IGF-1, SIRT1, and FOXOs The PI3K-PKB/AKT pathway is the canonical pathway regulating the transcriptional activity of FOXOs