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Non-lethal inhibition of gut microbial trimethylamine production for the treatment of atherosclerosis

mean age 56.4 3.1 years) before KT, 1 and 2 months after transplantation (Fig

Its multifaceted actions contribute to its neuroprotective and cognitive-enhancing properties, making it a well-established therapy for brain health and healing in various clinical contexts

In astrocytes, Nrf2 activators promote the translocation of Nrf2 from the cytoplasm to the nucleus, where it binds to the antioxidant response element (ARE), upregulating the expression of a series of antioxidant and detoxifying enzymes such as heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1)

In addition to this, many studies have found that GABA amelioration of insomnia may be associated with biological processes such as inhibition of nervous system inflammation, repair of oxidative damage, neuroprotection and melatonin regulation [16,31]