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Over time, these conditions become harder and harder to overcome, like trying to scale Cabrillo National Monument in Chula Vista, CA, without climbing gear

GLP-1 receptor agonists (like semaglutide or tirzepatide) are medications that mimic a natural hormone called glucagon-like peptide-1

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Buckey JC, Phillips SD, Anderson AP, Chepko AB, Archambault-Leger V, Gui J, et al

Editors note: If you or someone you know is struggling with suicidal thoughts or mental health matters, please call the 988 Suicide & Crisis Lifeline by dialing 988 to connect with a trained counselor, or visit the 988 Lifeline website

Compared to placebo, GLP-1 receptor agonists reduced the risk of kidney failure by 16% and the worsening of kidney function by 22% (defined by a drop in estimated glomerular filtration ratea measure of how much blood the kidneys filter clean every minuteof at least 50%)
