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Interestingly, because apoptosis is used by the host as an antiviral defense strategy in order to eliminate virus, HSV-1 encodes numerous viral determinants for evading it (Figure 2A), which overall may favor virus persistence in the host by remaining in a viable substrate as a long-term niche for latency, which could produce chronic inflammation due to recurrent asymptomatic reactivations (Perng et al., 2000)

Gratton, J
methodology, I.M.C.-S

49 RybakL

Aging: As individuals age, the tissues supporting the veins can weaken

12-Lipoxygenase is a critical mediator of type II pneumocyte senescence, macrophage polarization and pulmonary fibrosis after irradiation
