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Reply to Associations of semaglutide with first-time diagnosis of Alzheimers disease in patients with type 2 diabetes: target trial emulation using nationwide real-world data in the US

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Tirzepatide administration led to a significant reduction in GLP-1R expression in the cortex and hippocampus, as evidenced by decreased phosphorylation of protein kinase A (PKA) substrates at Thr197
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