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In particular, incomplete retrieval of grey literature and insufficient documentation of study-exclusion decisions could lead to overestimation of benefits or underdetection of harms, while the infrequent propagation of primary-study bias into meta-analytic models reduces confidence in the magnitude of pooled effects

Overall, indirect comparisons suggest that SGLT2 inhibitors may offer greater preservation of eGFR than GLP-1 receptor agonists in a broader population of people with type 2 diabetes mellitus and CKD

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During rapid weight loss, CoQ10 levels can decline, potentially contributing to fatigue and muscle weakness

Current treatment approaches in the UK, as recommended by NICE, emphasise a multidisciplinary strategy

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