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Retatrutide might lead to more stomach trouble because of higher doses, but the long-term data are not definitive yet

The most common effects are gastrointestinal: oily spotting, increased flatulence with oily discharge, loose or urgent stools, and sometimes steatorrhea

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Bupropion is an antidepressant that can help control cravings, while naltrexone is used to reduce the desire for food and addictive behaviours

With the right knowledge, the right tools (such as quality insulin syringes), and a conscientious approach, retatrutide can be used safely in a research context

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