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Scientists found that GLP-1 receptor mRNA levels in the nucleus tractus solitarius (NTS) dropped after 1-2 weeks of treatment, matching when the drug started becoming less effective [24]

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Intravenous administration of these formulations, particularly the combination of 131 I-ELP-POP and exendin-4-ELP-POP, resulted in marked tumor regression in insulinoma xenograft models

10.1111/j.1432-1033.1997.00243.x [DOI] [PubMed] [Google Scholar] 14.Smith RE, Talhouk JW, Brown EE, Edgar SE

Dehydration secondary to nausea, vomiting, or diarrhoea further compounds fatigue