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Description

The clinical relevance in humans is uncertain, but use is contraindicated in patients with MTC history or MEN 2

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[1] The most frequently reported gastrointestinal side effects include: Nausea (very common, affecting more than 1 in 10 patients) Diarrhoea (very common, affecting more than 1 in 10 patients) Vomiting (common to very common, depending on dose) Decreased appetite (very common) Constipation Abdominal pain or discomfort Dyspepsia (indigestion) Belching , which may occasionally have a sulphurous odour These symptoms typically occur because GLP-1 receptor agonists slow gastric emptyingthe rate at which food leaves the stomachand alter gastrointestinal motility

GLP-1 use is linked to fewer kidney problems and lower blood sugar compared to other diabetes drugs RA patients who took GLP-1 or SGLT2 drugs had fewer flares Semaglutide was connected to better joint outcomes