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This double-blind, placebo-controlled trial randomized (1:1) adults with body mass index 30 or 27 kg/m 2 and at least one obesity-related complication (excluding diabetes), who achieved 5.0% weight reduction after a 12-week intensive lifestyle intervention, to tirzepatide maximum tolerated dose (10 or 15 mg) or placebo once weekly for 72 weeks ( n = 579)

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A 2024 network metaanalysis of 38 RCTs in type 2 diabetes reported significant gains in brachial flowmediated dilation (FMD) and reductions in pulsewave velocity (PWV) versus placebo, consistent with enhanced NOdependent vasodilation [37]

Furthermore, these medications can have significant side effects, with cognitive impairment particularly reported in the case of topiramate

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