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DENV up-regulates the HMG-CoA reductase activity through the impairment of AMPK phosphorylation: a potential antiviral target

Practical Guidance (Interim) Clinicians should counsel that current evidence does not justify routine therapeutic use outside registered ethically approved research protocols and that online sourcing introduces quality, legal and professional risk

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The practical implication is that selumetinib is likely to remain the only approved targeted option for adult NF1-PN for several years, a position that gives Alexion/AstraZeneca time to build real-world evidence, establish treatment guidelines, and optimize dosing protocols across the pediatric-to-adult continuum

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The need for the list took on new urgency in 2012, when more than 60 people died from fungal meningitis infections contracted from a drug produced at a compounding facility and dispensed to hundreds of people