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A few of the most significant contributors to NAD+ depletion include: CD38: An enzyme that breaks down NAD+ and becomes more active with age, especially in response to inflammation

In patients with neurological manifestations, prompt treatment can halt progression and potentially reverse symptoms

B vitamins are also water-soluble, which means any excess leaves your body through urine

Most doctors recommend carrying around a 64-oz container of water and sipping on it throughout the day, except for 30 minutes before and after meals

For a 20mg vial, you have 20,000 mcg to work with

Numbness or tingling in the hands and feet