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This result clearly demonstrated that both GSTM1 and GSTM2 had the same functional efficiency

10.1038/jcbfm.2009.262 138 ShapiraM.LichtA.MilmanA.PickC

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Through the exosomeglialinflammation cascade, this mechanism facilitates the spread of focal neuronal injury to adjacent brain regions, thereby accelerating region-specific neurodegeneration and functional impairment in Alzheimers disease (Figure 3)

Meanwhile, the upregulation of MDM2 suggests that the p53 signaling pathway may be inhibited, which to a certain extent reduces the ability of cells to repair DNA damage and may prompt cells to evade apoptotic mechanisms, further accelerating tumor progression

J.BilalS.EeC